MGAT4B

Across TCGA pan-cancer cohorts, MGAT4B RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated MGAT4B data layer compared with 5 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in kidney chromophobe (KICH), where higher MGAT4B RNA is associated with worse overall survival. In most high-consensus cancer types, elevated MGAT4B expression acts as an unfavorable survival marker, although some lineages such as COAD and READ show a favorable association.

KICH, LGG, and COAD are the cancer types where MGAT4B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	OS	Median	III,IV	0.733	1.000	.001	55	view →
LGG	DFS	Median	All	0.623	0.851	<.001	54	view →
COAD	DFS	Quartile	IV	0.689	0.324	<.001	50	view →
BRCA	OS	Tertile	II,III,IV	0.474	0.626	.005	44	view →
CESC	DFS	Quartile	All	0.462	0.711	.001	42	view →
HNSC	OS	Quartile	All	0.495	0.839	<.001	42	view →
LIHC	DFS	Median	All	0.477	0.605	.001	30	view →
UCS	DFS	Median	II,III,IV	0.218	0.502	.009	28	view →
LAML	DFS	Median	All	0.281	0.464	.019	26	view →
UVM	OS	Tertile	All	0.626	0.850	.009	25	view →
LUSC	OS	Median	III,IV	0.450	0.682	.008	24	view →
ESCA	DFS	Tertile	III,IV	0.327	0.579	.013	19	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

MGAT4B–KICH (OS)

Open the KICH breakdown →