MGAT3

Across TCGA patient cohorts, MGAT3 mutation is significantly associated with the RNA expression of many other genes, with 5,726 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MGAT3-associated genes across cancer lineages are CST3, GPR143, and TLE6. Each is linked with MGAT3 in more than 2 cancer types. Because this analysis shows association rather than direction, both MGAT3-to-partner and partner-to-MGAT3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CST3 grouped by MGAT3-low versus MGAT3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MGAT3→partner) and Y-score (partner→MGAT3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CST3 →	-0.470	-1.906	.001	<.001	3	3
UCEC	GPR143 →	-0.474	-1.968	.005	.002	3	3
UCEC	TLE6 →	+0.709	+1.743	<.001	<.001	3	3
UCEC	TIMM50 →	+0.345	+1.949	<.001	<.001	3	3
UCEC	TYRP1 →	-0.343	-3.154	.002	<.001	3	3
UCEC	OTX1 →	+0.571	+1.917	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,726 associations by consensus.

CST3 by MGAT3 expression — UCEC

Explore this box plot interactively →