MFSD4B

Across TCGA cell cohorts, MFSD4B mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MFSD4B-associated genes across cancer lineages are FOXI2, OPALIN, and GPX5. Each is linked with MFSD4B in more than 1 cancer types. Because this analysis shows association rather than direction, both MFSD4B-to-partner and partner-to-MFSD4B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXI2 grouped by MFSD4B-low versus MFSD4B-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MFSD4B→partner) and Y-score (partner→MFSD4B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FOXI2 →	+0.024	+5.217	<.001	<.001	3	1
LARGE_INTESTINE	OPALIN →	+0.006	+4.467	<.001	.004	3	1
LARGE_INTESTINE	GPX5 →	+0.206	+4.273	.004	.006	3	1
BLOOD_Leukemia	PAX1 →	+0.027	+4.060	<.001	.003	3	1
BLOOD_Leukemia	ADAM30 →	+0.013	+4.984	<.001	.002	3	1
BLOOD_Leukemia	HCN4 →	+0.048	+3.855	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

FOXI2 by MFSD4B expression — LARGE_INTESTINE

Explore this box plot interactively →