MFSD4B

Across TCGA pan-cancer cohorts, MFSD4B RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated MFSD4B data layer compared with 4 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher MFSD4B RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MFSD4B expression acts as an unfavorable survival marker, although some lineages such as UCS and READ show a favorable association.

BLCA, MESO, and LIHC are the cancer types where MFSD4B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	DFS	Median	All	0.242	0.420	<.001	140	view →
MESO	OS	Median	All	0.281	0.490	<.001	81	view →
LIHC	DFS	Tertile	All	0.435	0.613	<.001	73	view →
LGG	OS	Median	All	0.735	0.880	<.001	47	view →
COAD	DFS	Quartile	II,III,IV	0.272	0.615	<.001	45	view →
CESC	DFS	Median	II,III,IV	0.348	0.693	.007	44	view →
UVM	DFS	Median	III,IV	0.211	0.884	.002	44	view →
HNSC	OS	Median	III,IV	0.410	0.681	.002	40	view →
ESCA	OS	Median	All	0.592	0.800	<.001	38	view →
UCS	OS	Median	IV	0.817	0.302	.002	36	view →
READ	OS	Median	II,III,IV	0.960	0.393	.004	23	view →
KICH	DFS	Quartile	All	0.466	0.938	.006	22	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

MFSD4B–BLCA (DFS)

Open the BLCA breakdown →