MFRP

Across TCGA cell cohorts, MFRP mutation is significantly associated with the RNA expression of many other genes, with 28 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MFRP-associated genes across cancer lineages are OR6J1, OR1M1, and CLRN1. Each is linked with MFRP in more than 1 cancer types. Because this analysis shows association rather than direction, both MFRP-to-partner and partner-to-MFRP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR6J1 grouped by MFRP-low versus MFRP-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MFRP→partner) and Y-score (partner→MFRP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OR6J1 →	+0.040	+3.234	<.001	.008	3	2
LUNG_SCLC	OR1M1 →	+0.016	+5.643	<.001	.002	3	1
SKIN	CLRN1 →	+0.680	+3.793	<.001	.007	3	1
SKIN	OR56B1 →	+0.036	+4.688	.002	<.001	3	1
SKIN	FAM9A →	+0.106	+3.684	<.001	.006	3	1
SKIN	SCYGR10 →	+0.191	+3.684	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

OR6J1 by MFRP expression — BLOOD_Leukemia

Explore this box plot interactively →