MEX3D

Across TCGA cell cohorts, MEX3D mutation is significantly associated with the RNA expression of many other genes, with 829 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MEX3D-associated genes across cancer lineages are DEFA6, ADH1A, and ARID2. Each is linked with MEX3D in more than 1 cancer types. Because this analysis shows association rather than direction, both MEX3D-to-partner and partner-to-MEX3D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFA6 grouped by MEX3D-low versus MEX3D-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MEX3D→partner) and Y-score (partner→MEX3D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	DEFA6 →	+0.111	+5.196	.004	.005	3	2
LARGE_INTESTINE	ADH1A →	+0.076	+2.183	.009	.007	3	2
LARGE_INTESTINE	ARID2 →	+0.557	+3.364	.001	.002	3	2
LARGE_INTESTINE	ZFP2 →	+0.503	+3.451	<.001	.002	3	2
SKIN	ARMC3 →	+0.160	+3.478	<.001	.005	3	2
OVARY	OR12D3 →	+0.016	+5.807	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 829 associations by consensus.

DEFA6 by MEX3D expression — OVARY

Explore this box plot interactively →