METTL4

Across TCGA patient cohorts, METTL4 RNA expression is significantly associated with the protein abundance of many other proteins, with 14,185 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible METTL4-associated proteins across cancer lineages are SMCHD1, AQR, and RFC2. Each is linked with METTL4 in more than 9 cancer types. Because this analysis shows association rather than direction, both METTL4-to-partner and partner-to-METTL4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, METTL4 versus SMCHD1 in GBM, with a Pearson correlation of 0.50.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (METTL4→partner) and Y-score (partner→METTL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SMCHD1 →	+0.590	+0.598	<.001	<.001	3	10
GBM	AQR →	+0.306	+0.458	<.001	<.001	3	7
GBM	RFC2 →	+0.408	+0.413	.001	.001	3	6
LSCC	RNMT →	+0.319	+0.513	<.001	<.001	3	6
GBM	SMC5 →	+0.386	+0.524	<.001	<.001	3	6
GBM	PPIL4 →	+0.376	+0.492	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,185 associations by consensus.

METTL4 vs SMCHD1 — GBM

Explore this scatter interactively →