METTL4

Across TCGA patient cohorts, METTL4 protein abundance is significantly associated with the RNA expression of many other genes, with 2,082 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible METTL4-associated genes across cancer lineages are PHF13, CDK17, and CYTH4. Each is linked with METTL4 in more than 1 cancer types. Because this analysis shows association rather than direction, both METTL4-to-partner and partner-to-METTL4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, METTL4 versus PHF13 in LUAD, with a Pearson correlation of 0.69.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (METTL4→partner) and Y-score (partner→METTL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PHF13 →	+0.737	+0.518	<.001	.001	3	2
LUAD	CDK17 →	+0.572	+0.503	.004	.003	3	2
LUAD	CYTH4 →	+0.814	+0.521	.001	.001	3	1
LUAD	RASL10A →	+0.403	+0.596	.001	<.001	3	1
LUAD	AP1B1 →	+0.533	+0.498	.001	.002	3	1
LUAD	PDGFB →	+0.928	+0.625	.006	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,082 associations by consensus.

METTL4 vs PHF13 — LUAD

Explore this scatter interactively →