METTL4

Across TCGA patient cohorts, METTL4 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible METTL4-associated genes across cancer lineages are PDCD4, VHL, and EGFR_pY1068. Each is linked with METTL4 in more than 1 cancer types. Because this analysis shows association rather than direction, both METTL4-to-partner and partner-to-METTL4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by METTL4-low versus METTL4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (METTL4→partner) and Y-score (partner→METTL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.505	-2.000	.006	.010	3	2
UCEC	VHL →	-0.782	-1.584	.003	.036	3	2
UCEC	EGFR_pY1068 →	-0.227	-2.502	.021	.002	3	1
UCEC	eIF4E →	+0.191	+2.502	.021	.002	3	1
UCEC	ERK2 →	+0.157	+1.584	.038	.036	3	1
UCEC	INPP4B →	-0.311	-2.459	.014	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

PDCD4 by METTL4 expression — UCEC

Explore this box plot interactively →