METTL4

Across TCGA cell cohorts, METTL4 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible METTL4-associated genes across cancer lineages are HHLA1, OR1L3, and TMEM196. Each is linked with METTL4 in more than 1 cancer types. Because this analysis shows association rather than direction, both METTL4-to-partner and partner-to-METTL4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HHLA1 grouped by METTL4-low versus METTL4-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (METTL4→partner) and Y-score (partner→METTL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	HHLA1 →	+0.011	+4.551	<.001	.004	3	1
BLOOD_Leukemia	OR1L3 →	+0.057	+4.276	.008	.007	3	1
BLOOD_Leukemia	TMEM196 →	+0.045	+4.874	<.001	.002	3	1
BLOOD_Leukemia	GSG1L2 →	+0.043	+4.969	<.001	.003	3	1
BLOOD_Leukemia	C5orf67 →	+0.089	+4.409	.007	.005	3	1
BLOOD_Leukemia	OR4A47 →	+0.016	+4.539	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

HHLA1 by METTL4 expression — BLOOD_Leukemia

Explore this box plot interactively →