METTL2A

Across TCGA patient cohorts, METTL2A mutation is significantly associated with the RNA expression of many other genes, with 2,491 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible METTL2A-associated genes across cancer lineages are IGKV2D-19, MIR4802, and RNU6-1292P. Each is linked with METTL2A in more than 1 cancer types. Because this analysis shows association rather than direction, both METTL2A-to-partner and partner-to-METTL2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGKV2D-19 grouped by METTL2A-low versus METTL2A-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (METTL2A→partner) and Y-score (partner→METTL2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	IGKV2D-19 →	+0.258	+4.899	<.001	.005	3	2
COAD	MIR4802 →	+1.372	+4.446	<.001	.006	3	2
UCEC	RNU6-1292P →	+0.252	+3.132	<.001	.005	3	2
BLCA	VDAC2P2 →	+0.079	+4.178	<.001	.009	3	1
BLCA	MIR3667 →	+0.692	+4.299	<.001	.007	3	1
UCEC	DYNLL2 →	+0.488	+2.823	.002	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,491 associations by consensus.

IGKV2D-19 by METTL2A expression — BLCA

Explore this box plot interactively →