METTL21C

Across TCGA patient cohorts, METTL21C mutation is significantly associated with the RNA expression of many other genes, with 533 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible METTL21C-associated genes across cancer lineages are OR52Y1P, NUDT4B, and RNU6-451P. Each is linked with METTL21C in more than 1 cancer types. Because this analysis shows association rather than direction, both METTL21C-to-partner and partner-to-METTL21C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR52Y1P grouped by METTL21C-low versus METTL21C-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (METTL21C→partner) and Y-score (partner→METTL21C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	OR52Y1P →	+0.055	+5.155	<.001	.002	3	2
UCEC	NUDT4B →	+0.050	+3.036	<.001	.002	3	2
UCEC	RNU6-451P →	+0.487	+2.664	<.001	.002	3	2
UCEC	MIR629 →	+0.225	+3.466	<.001	.003	3	2
UCEC	IGHD6-19 →	+0.666	+2.835	<.001	.003	3	2
UCEC	LINC02438 →	+0.694	+3.724	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 533 associations by consensus.

OR52Y1P by METTL21C expression — LUAD

Explore this box plot interactively →