METTL17

Across TCGA patient cohorts, METTL17 mutation is significantly associated with the RNA expression of many other genes, with 671 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible METTL17-associated genes across cancer lineages are LINC00613, RNU6-144P, and USP9YP10. Each is linked with METTL17 in more than 1 cancer types. Because this analysis shows association rather than direction, both METTL17-to-partner and partner-to-METTL17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC00613 grouped by METTL17-low versus METTL17-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (METTL17→partner) and Y-score (partner→METTL17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	LINC00613 →	+0.257	+7.741	<.001	.009	3	2
BRCA	RNU6-144P →	+0.489	+5.506	<.001	.005	3	2
LGG	USP9YP10 →	+0.049	+7.977	<.001	.007	3	2
UCEC	ZIC2 →	+1.643	+2.608	.001	.006	3	2
UCEC	PCSK1N →	-1.912	-3.584	<.001	.002	3	2
STAD	TTTY7 →	+0.033	+3.366	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 671 associations by consensus.

LINC00613 by METTL17 expression — COAD

Explore this box plot interactively →