METTL15

Across TCGA patient cohorts, METTL15 protein abundance is significantly associated with the RNA expression of many other genes, with 5,494 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible METTL15-associated genes across cancer lineages are MAN1C1, ADAMTS10, and GAB3. Each is linked with METTL15 in more than 3 cancer types. Because this analysis shows association rather than direction, both METTL15-to-partner and partner-to-METTL15 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, METTL15 versus MAN1C1 in HNSC, with a Pearson correlation of -0.31.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (METTL15→partner) and Y-score (partner→METTL15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MAN1C1 →	-0.656	-0.194	<.001	.002	3	4
UCEC	ADAMTS10 →	-0.678	-0.318	<.001	.001	3	4
BRCA	GAB3 →	-0.558	-0.302	<.001	.007	3	4
BRCA	IL16 →	-0.626	-0.259	<.001	.006	3	4
LUAD	CBX7 →	-0.549	-0.370	<.001	<.001	3	3
OV	AEBP1 →	-1.461	-0.350	.003	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,494 associations by consensus.

METTL15 vs MAN1C1 — HNSC

Explore this scatter interactively →