METTL15

Across TCGA pan-cancer cohorts, METTL15 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of METTL15’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where METTL15 RNA is repressed in tumor relative to normal tissue. In most cancer types METTL15 is over-expressed in tumor, although a few such as THCA and UCEC show the opposite, repressed pattern.

THCA, LIHC, and CHOL are the cancer types where METTL15 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in METTL15 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	All	−0.424	<.001	10	view →
LIHC	Male	All	+0.661	<.001	9	view →
CHOL	All	All	+0.933	<.001	5	view →
KIRC	All	All	+0.218	<.001	5	view →
STAD	All	II,III,IV	+0.415	.004	4	view →
BRCA	All	All	+0.250	.001	4	view →
LUAD	All	All	+0.281	.001	3	view →
ESCA	All	II,III,IV	+0.905	.037	2	view →
UCEC	All	All	−0.551	<.001	2	view →
HNSC	All	All	+0.222	.022	2	view →
COAD	Female	IV	−0.860	.012	1	view →
KICH	Female	All	−0.451	.049	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

METTL15–THCA

Open the THCA breakdown →