METAP1D

Across TCGA patient cohorts, METAP1D mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible METAP1D-associated genes across cancer lineages are c-Met_pY1235, eEF2, and FoxM1. Each is linked with METAP1D in more than 1 cancer types. Because this analysis shows association rather than direction, both METAP1D-to-partner and partner-to-METAP1D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, c-Met_pY1235 grouped by METAP1D-low versus METAP1D-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (METAP1D→partner) and Y-score (partner→METAP1D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	c-Met_pY1235 →	+0.077	+2.321	.038	.035	3	2
UCEC	eEF2 →	+0.524	+2.321	.003	.035	3	1
UCEC	FoxM1 →	+0.366	+2.321	.004	.035	3	1
UCEC	FOXO3a_pS318_S321 →	-0.160	-3.160	.010	.019	3	1
UCEC	GATA6 →	-0.202	-2.314	.009	.035	3	1
UCEC	Heregulin →	-0.175	-2.321	.004	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

c-Met_pY1235 by METAP1D expression — UCEC

Explore this box plot interactively →