METAP1D

Across TCGA pan-cancer cohorts, METAP1D RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of METAP1D’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where METAP1D RNA is more highly expressed in tumor relative to normal tissue. In most cancer types METAP1D is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

COAD, LUAD, and HNSC are the cancer types where METAP1D tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in METAP1D RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	IV	+1.112	<.001	10	view →
LUAD	Male	II,III,IV	+0.937	<.001	9	view →
HNSC	Male	III,IV	+0.564	<.001	9	view →
KICH	Female	II,III,IV	−1.661	<.001	8	view →
LIHC	Male	All	+0.714	<.001	8	view →
THCA	Female	II,III,IV	−0.635	<.001	7	view →
KIRC	Male	All	+0.320	<.001	7	view →
STAD	Male	II,III,IV	+0.929	<.001	6	view →
KIRP	All	II,III,IV	+0.543	.008	6	view →
BRCA	Female	II,III,IV	−0.454	<.001	6	view →
LUSC	Male	II,III,IV	+0.700	<.001	5	view →
CHOL	All	All	+1.423	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

METAP1D–COAD

Open the COAD breakdown →