METAP1D

Across TCGA pan-cancer cohorts, METAP1D RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated METAP1D data layer compared with 2 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in thyroid carcinoma (THCA), where higher METAP1D RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated METAP1D expression acts as an unfavorable survival marker, although some lineages such as READ and BRCA show a favorable association.

THCA, ACC, and READ are the cancer types where METAP1D RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THCA	DFS	Quartile	II,III,IV	0.468	0.838	<.001	92	view →
ACC	DFS	Tertile	All	0.152	0.812	<.001	80	view →
READ	OS	Quartile	III,IV	0.872	0.269	<.001	51	view →
LUAD	OS	Median	All	0.768	0.897	<.001	47	view →
LIHC	DFS	Median	All	0.196	0.372	<.001	43	view →
BRCA	OS	Tertile	III,IV	0.972	0.843	<.001	29	view →
KIRP	DFS	Tertile	IV	0.176	0.588	.002	29	view →
STAD	DFS	Median	IV	0.307	0.633	.012	24	view →
COAD	DFS	Quartile	All	0.696	0.822	.009	23	view →
HNSC	DFS	Quartile	All	0.313	0.465	.010	18	view →
MESO	DFS	Median	II,III,IV	0.303	0.597	.013	15	view →
BLCA	DFS	Tertile	II,III,IV	0.431	0.298	.020	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

METAP1D–THCA (DFS)

Open the THCA breakdown →