METAP1D

Across TCGA cell cohorts, METAP1D mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible METAP1D-associated genes across cancer lineages are ADAM2, IFNA6, and HAO2. Each is linked with METAP1D in more than 1 cancer types. Because this analysis shows association rather than direction, both METAP1D-to-partner and partner-to-METAP1D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADAM2 grouped by METAP1D-low versus METAP1D-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (METAP1D→partner) and Y-score (partner→METAP1D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	ADAM2 →	+0.033	+5.000	<.001	.006	3	1
PANCREAS	IFNA6 →	+0.013	+5.614	<.001	.002	3	1
BLOOD_Leukemia	HAO2 →	+0.061	+4.234	<.001	.003	3	1
BLOOD_Leukemia	CST5 →	+0.412	+3.551	<.001	.009	3	1
BLOOD_Leukemia	OR10K2 →	+0.047	+3.705	<.001	.007	3	1
BLOOD_Leukemia	HELT →	+0.013	+4.384	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

ADAM2 by METAP1D expression — PANCREAS

Explore this box plot interactively →