MET

Across TCGA patient cohorts, MET protein abundance is significantly associated with the RNA expression of many other genes, with 13,581 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible MET-associated genes across cancer lineages are TNFRSF12A, CAV2, and AREG. Each is linked with MET in more than 7 cancer types. Because this analysis shows association rather than direction, both MET-to-partner and partner-to-MET results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MET versus TNFRSF12A in CCRCC, with a Pearson correlation of 0.48.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MET→partner) and Y-score (partner→MET) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	TNFRSF12A →	+1.301	+0.605	<.001	<.001	3	8
HNSC	CAV2 →	+1.306	+0.649	<.001	<.001	3	7
HNSC	AREG →	+2.219	+0.541	<.001	<.001	3	6
HNSC	SDC4 →	+0.844	+0.387	<.001	<.001	3	6
BRCA	TES →	+0.974	+0.738	<.001	<.001	3	6
LSCC	MYOF →	+0.783	+0.604	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,581 associations by consensus.

MET vs TNFRSF12A — CCRCC

Explore this scatter interactively →