MET

Across TCGA pan-cancer cohorts, MET RNA differs between tumor and matched normal tissue in 17 of 18 cancer types tested, making tumor–normal expression one of MET’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where MET RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MET is over-expressed in tumor, although a few such as BRCA and PRAD show the opposite, repressed pattern.

HNSC, COAD, and KIRP are the cancer types where MET tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MET RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+2.324	<.001	12	view →
COAD	Male	All	+2.237	<.001	12	view →
KIRP	All	IV	+3.122	<.001	11	view →
THCA	Male	III,IV	+2.827	<.001	11	view →
KIRC	Male	All	+1.717	<.001	11	view →
STAD	Male	II,III,IV	+2.207	<.001	8	view →
BLCA	All	III,IV	+1.569	<.001	8	view →
LIHC	Male	All	+0.726	<.001	7	view →
BRCA	All	III,IV	−2.423	<.001	6	view →
LUAD	All	All	+0.784	<.001	6	view →
KICH	All	All	+0.914	.001	5	view →
READ	All	All	+1.367	.003	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 17 lineages.

MET–HNSC

Open the HNSC breakdown →