MET

Across TCGA pan-cancer cohorts, MET RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated MET data layer compared with 10 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher MET RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MET expression acts as an unfavorable survival marker, although some lineages such as ACC and COAD show a favorable association.

UVM, PAAD, and LGG are the cancer types where MET RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.328	0.787	<.001	126	view →
PAAD	OS	Median	All	0.257	0.535	<.001	83	view →
LGG	OS	Median	All	0.755	0.862	<.001	47	view →
STAD	OS	Tertile	II,III,IV	0.355	0.674	.004	30	view →
MESO	DFS	Median	II,III,IV	0.234	0.667	.001	24	view →
BLCA	DFS	Quartile	All	0.436	0.721	.005	22	view →
HNSC	OS	Median	All	0.716	0.785	.018	20	view →
GBM	OS	Quartile	All	0.186	0.544	.001	19	view →
ACC	OS	Median	II,III,IV	0.945	0.757	.009	17	view →
OV	OS	Median	II,III,IV	0.276	0.369	.013	16	view →
COAD	OS	Median	IV	0.718	0.348	.011	9	view →
READ	DFS	Median	II,III,IV	0.780	0.263	.020	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

MET–UVM (DFS)

Open the UVM breakdown →