MET

Across TCGA patient cohorts, MET mutation is significantly associated with the RNA expression of many other genes, with 8,802 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MET-associated genes across cancer lineages are ERH, PSMC3IP, and WRAP53. Each is linked with MET in more than 4 cancer types. Because this analysis shows association rather than direction, both MET-to-partner and partner-to-MET results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERH grouped by MET-low versus MET-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MET→partner) and Y-score (partner→MET) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	ERH →	+0.421	+3.212	.002	.009	3	5
UCEC	PSMC3IP →	+0.746	+1.702	<.001	<.001	3	4
COAD	WRAP53 →	+0.523	+3.652	<.001	.001	3	4
UCEC	RPL23AP82 →	+0.421	+1.425	<.001	<.001	3	4
KIRP	SNRPD3 →	+0.385	+3.853	.001	<.001	3	4
UCEC	PHF5A →	+0.557	+2.169	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,802 associations by consensus.

ERH by MET expression — BLCA

Explore this box plot interactively →