MET

Across TCGA patient cohorts, MET mutation is significantly associated with the total protein of many other genes, with 101 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MET-associated genes across cancer lineages are ERK2, INPP4B, and GAPDH. Each is linked with MET in more than 2 cancer types. Because this analysis shows association rather than direction, both MET-to-partner and partner-to-MET results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by MET-low versus MET-high in KIRP.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MET→partner) and Y-score (partner→MET) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIRP	ERK2 →	+0.241	+2.222	.037	.009	3	3
COAD	INPP4B →	-0.481	-3.169	.004	.017	3	3
COAD	GAPDH →	+0.490	+2.330	.032	.020	3	3
SKCM	p38-MAPK →	+0.115	+2.824	.045	.034	3	3
UCEC	Annexin-1 →	+0.482	+2.221	<.001	<.001	3	3
UCEC	EGFR_pY1068 →	-0.266	-2.523	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 101 associations by consensus.

ERK2 by MET expression — KIRP

Explore this box plot interactively →