MET

Across TCGA cell cohorts, MET RNA expression is significantly associated with the go_rna of many other GO terms, with 5,322 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible MET-associated GO terms across cancer lineages are Endothelial cell morphogenesis, Positive regulation of calcium ion transport into cytosol, and Regulation of actin filament polymerization. Each is linked with MET in more than 13 cancer types. Because this analysis shows association rather than direction, both MET-to-partner and partner-to-MET results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Endothelial cell morphogenesis grouped by MET-low versus MET-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MET→partner) and Y-score (partner→MET) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Endothelial cell morphogenesis →	+0.965	+2.316	<.001	<.001	3	14
BREAST	Positive regulation of calcium ion transport into cytosol →	+0.275	+2.649	<.001	<.001	3	13
STOMACH	Regulation of actin filament polymerization →	+0.081	+2.969	<.001	<.001	3	12
BREAST	Negative regulation of actin filament depolymerization →	+0.196	+3.563	<.001	<.001	3	12
STOMACH	Negative regulation of actin filament polymerization →	+0.147	+3.067	<.001	<.001	3	12
LUNG_NSCLC_LUSC	Hepatocyte growth factor receptor signaling pathway →	+0.274	+2.136	<.001	.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,322 associations by consensus.

Endothelial cell morphogenesis by MET expression — BLOOD_Lymphoma

Explore this box plot interactively →