MET

Across TCGA cell cohorts, MET mutation is significantly associated with the RNA expression of many other genes, with 104 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MET-associated genes across cancer lineages are OR2AG1, C1QC, and LY6G6F. Each is linked with MET in more than 1 cancer types. Because this analysis shows association rather than direction, both MET-to-partner and partner-to-MET results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2AG1 grouped by MET-low versus MET-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MET→partner) and Y-score (partner→MET) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	OR2AG1 →	+0.046	+3.857	<.001	.002	3	2
SKIN	C1QC →	+0.016	+2.518	<.001	.006	3	2
LUNG_NSCLC_LUSC	LY6G6F →	+0.036	+4.643	<.001	.008	3	1
OESOPHAGUS	CST9L →	+0.024	+3.392	<.001	.007	3	1
OESOPHAGUS	WFDC13 →	+0.082	+3.523	<.001	.009	3	1
OESOPHAGUS	OR10A4 →	+0.018	+3.857	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 104 associations by consensus.

OR2AG1 by MET expression — OESOPHAGUS

Explore this box plot interactively →