MESP1

Across TCGA patient cohorts, MESP1 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MESP1-associated genes across cancer lineages are OFD1P8Y, RNA5SP426, and OR6C72P. Each is linked with MESP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MESP1-to-partner and partner-to-MESP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OFD1P8Y grouped by MESP1-low versus MESP1-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MESP1→partner) and Y-score (partner→MESP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	OFD1P8Y →	+0.049	+7.924	<.001	.008	3	1
UCEC	RNA5SP426 →	+0.421	+4.868	<.001	.004	3	1
UCEC	OR6C72P →	+0.116	+4.442	<.001	.007	3	1
UCEC	MIR760 →	+0.990	+3.960	<.001	.007	3	1
UCEC	EIF3JP1 →	+0.408	+3.690	<.001	.009	3	1
UCEC	RN7SL316P →	+0.512	+3.943	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

OFD1P8Y by MESP1 expression — LUSC

Explore this box plot interactively →