MESP1

Across TCGA pan-cancer cohorts, MESP1 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated MESP1 data layer compared with 1 for mutation status.

The strongest signal is observed in uveal melanoma (UVM), where higher MESP1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MESP1 expression acts as an unfavorable survival marker, although some lineages such as KIRP and READ show a favorable association.

UVM, KIRP, and LIHC are the cancer types where MESP1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	III,IV	0.169	0.758	<.001	97	view →
KIRP	DFS	Tertile	II,III,IV	0.940	0.239	.005	57	view →
LIHC	OS	Quartile	All	0.484	0.782	.004	34	view →
COAD	OS	Quartile	IV	0.243	1.000	.006	28	view →
KICH	DFS	Quartile	III,IV	0.028	0.764	.010	25	view →
READ	DFS	Tertile	IV	0.789	0.274	.008	24	view →
ESCA	DFS	Median	All	0.450	0.608	.008	22	view →
LAML	DFS	Tertile	All	0.442	0.686	.003	16	view →
CHOL	DFS	Median	II,III,IV	0.121	0.626	.002	15	view →
SKCM	DFS	Median	II,III,IV	0.729	0.630	.029	12	view →
STAD	DFS	Median	IV	0.562	0.161	.023	9	view →
DLBC	DFS	Median	II,III,IV	0.543	0.882	.031	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

MESP1–UVM (DFS)

Open the UVM breakdown →