MELK

Across TCGA patient cohorts, MELK RNA expression is significantly associated with the protein abundance of many other proteins, with 23,197 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible MELK-associated proteins across cancer lineages are TOP2A_S1106, POLD1, and MCM2. Each is linked with MELK in more than 9 cancer types. Because this analysis shows association rather than direction, both MELK-to-partner and partner-to-MELK results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MELK versus TOP2A_S1106 in LUAD, with a Pearson correlation of 0.68.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (MELK→partner) and Y-score (partner→MELK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TOP2A_S1106 →	+1.306	+1.588	<.001	<.001	3	10
OV	POLD1 →	+0.441	+1.464	<.001	<.001	3	10
LUAD	MCM2 →	+0.873	+1.680	<.001	<.001	3	10
LUAD	MCM4 →	+0.933	+1.694	<.001	<.001	3	10
LUAD	MCM7 →	+0.890	+1.694	<.001	<.001	3	10
LUAD	MKI67_S2528 →	+1.967	+1.582	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 23,197 associations by consensus.

MELK vs TOP2A_S1106 — LUAD

Explore this scatter interactively →