MEIOB

Across TCGA patient cohorts, MEIOB mutation is significantly associated with the RNA expression of many other genes, with 1,235 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MEIOB-associated genes across cancer lineages are AKR1B1P3, MIR4710, and TRIM48. Each is linked with MEIOB in more than 1 cancer types. Because this analysis shows association rather than direction, both MEIOB-to-partner and partner-to-MEIOB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AKR1B1P3 grouped by MEIOB-low versus MEIOB-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MEIOB→partner) and Y-score (partner→MEIOB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	AKR1B1P3 →	+0.265	+4.242	<.001	.003	3	2
COAD	MIR4710 →	+0.799	+5.187	<.001	<.001	3	2
COAD	TRIM48 →	+0.114	+4.807	<.001	.004	3	2
UCEC	TAF15 →	+0.449	+2.425	.005	.002	3	1
UCEC	LINC01607 →	-0.768	-3.785	<.001	<.001	3	1
UCEC	RNU6-90P →	+0.387	+2.079	.003	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,235 associations by consensus.

AKR1B1P3 by MEIOB expression — COAD

Explore this box plot interactively →