MEIOB

Across TCGA pan-cancer cohorts, MEIOB RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated MEIOB data layer compared with 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher MEIOB RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated MEIOB expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and ACC are the cancer types where MEIOB RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	IV	0.575	0.280	<.001	82	view →
SKCM	OS	Tertile	III,IV	0.834	0.551	<.001	54	view →
ACC	DFS	Median	III,IV	0.275	0.734	<.001	47	view →
BLCA	OS	Tertile	III,IV	0.467	0.285	.008	38	view →
UCEC	DFS	Quartile	All	0.860	0.918	.005	32	view →
KIRC	OS	Median	II,III,IV	0.423	0.611	.004	23	view →
PRAD	DFS	Quartile	All	0.883	0.955	<.001	20	view →
THCA	DFS	Quartile	II,III,IV	0.906	0.662	.004	19	view →
LAML	DFS	Median	All	0.247	0.544	.009	16	view →
STAD	DFS	Median	III,IV	0.459	0.265	.023	14	view →
READ	DFS	Quartile	IV	0.278	0.688	.007	12	view →
COAD	OS	Median	III,IV	0.878	0.724	.026	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

MEIOB–HNSC (DFS)

Open the HNSC breakdown →