MEI4

Across TCGA cell cohorts, MEI4 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MEI4-associated genes across cancer lineages are OR2J2, CLDN17, and OR3A1. Each is linked with MEI4 in more than 1 cancer types. Because this analysis shows association rather than direction, both MEI4-to-partner and partner-to-MEI4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2J2 grouped by MEI4-low versus MEI4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MEI4→partner) and Y-score (partner→MEI4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR2J2 →	+0.024	+5.217	<.001	<.001	3	2
STOMACH	CLDN17 →	+0.030	+5.285	<.001	.003	3	1
LUNG_SCLC	OR3A1 →	+0.536	+4.523	<.001	.003	3	1
LUNG_SCLC	LILRA4 →	+0.133	+4.817	<.001	.001	3	1
LUNG_SCLC	KRTAP10-5 →	+0.058	+4.269	<.001	.005	3	1
LARGE_INTESTINE	MYF6 →	+0.014	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

OR2J2 by MEI4 expression — LARGE_INTESTINE

Explore this box plot interactively →