MEI4

Across TCGA pan-cancer cohorts, MEI4 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated MEI4 data layer compared with 1 for mutation status.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher MEI4 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated MEI4 expression acts as an unfavorable survival marker, although some lineages such as KIRC and LGG show a favorable association.

STAD, KIRC, and UCEC are the cancer types where MEI4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	OS	Median	All	0.501	0.655	<.001	121	view →
KIRC	DFS	Tertile	All	0.726	0.559	<.001	98	view →
UCEC	DFS	Median	All	0.769	0.872	<.001	80	view →
LGG	OS	Median	All	0.866	0.754	<.001	45	view →
LUAD	OS	Median	III,IV	0.209	0.374	.008	24	view →
ACC	OS	Quartile	All	0.892	0.283	.014	22	view →
UVM	DFS	Quartile	All	0.307	0.887	.003	17	view →
COAD	OS	Quartile	III,IV	0.956	0.598	.001	16	view →
DLBC	OS	Tertile	II,III,IV	0.640	1.000	.019	12	view →
TGCT	DFS	Tertile	All	0.947	0.738	.008	12	view →
BLCA	DFS	Median	II,III,IV	0.448	0.545	.008	11	view →
ESCA	DFS	Median	All	0.580	0.435	.018	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

MEI4–STAD (OS)

Open the STAD breakdown →