MEGF11

Across TCGA patient cohorts, MEGF11 mutation is significantly associated with the RNA expression of many other genes, with 3,552 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MEGF11-associated genes across cancer lineages are TIPIN, RN7SL83P, and EEF1E1-BLOC1S5. Each is linked with MEGF11 in more than 2 cancer types. Because this analysis shows association rather than direction, both MEGF11-to-partner and partner-to-MEGF11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TIPIN grouped by MEGF11-low versus MEGF11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MEGF11→partner) and Y-score (partner→MEGF11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TIPIN →	+0.528	+1.709	<.001	<.001	3	3
COAD	RN7SL83P →	+0.337	+4.392	<.001	.006	3	3
LUSC	EEF1E1-BLOC1S5 →	+0.077	+4.163	<.001	.001	3	3
CESC	SMAD1-AS1 →	+0.134	+3.705	<.001	.008	3	2
READ	LINC01849 →	+0.114	+4.653	<.001	.007	3	2
HNSC	TRAJ57 →	+0.477	+5.368	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,552 associations by consensus.

TIPIN by MEGF11 expression — UCEC

Explore this box plot interactively →