MEGF11

Across TCGA pan-cancer cohorts, MEGF11 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of MEGF11’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where MEGF11 RNA is repressed in tumor relative to normal tissue. In most cancer types MEGF11 is over-expressed in tumor, although a few such as LUSC and LUAD show the opposite, repressed pattern.

LUSC, COAD, and KIRP are the cancer types where MEGF11 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MEGF11 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	Male	All	−0.653	<.001	7	view →
COAD	All	All	+0.265	.001	6	view →
KIRP	Male	All	+0.986	.008	5	view →
LUAD	Female	II,III,IV	−0.923	<.001	5	view →
LIHC	All	II,III,IV	+0.025	.001	5	view →
KIRC	All	All	+0.608	<.001	3	view →
KICH	All	All	−0.565	.010	3	view →
STAD	All	II,III,IV	+0.261	.014	3	view →
CHOL	All	All	+0.124	.001	3	view →
BRCA	All	III,IV	−0.086	<.001	2	view →
THCA	All	All	+0.266	.020	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

MEGF11–LUSC

Open the LUSC breakdown →