MEGF11

Across TCGA pan-cancer cohorts, MEGF11 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated MEGF11 data layer compared with 8 for mutation status.

The strongest signal is observed in uveal melanoma (UVM), where higher MEGF11 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MEGF11 expression acts as an unfavorable survival marker, although some lineages such as LGG and DLBC show a favorable association.

UVM, LGG, and THYM are the cancer types where MEGF11 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Quartile	All	0.318	0.971	<.001	50	view →
LGG	DFS	Median	All	0.822	0.643	<.001	48	view →
THYM	OS	Median	All	0.729	1.000	<.001	36	view →
CESC	DFS	Tertile	All	0.400	0.675	.016	28	view →
MESO	DFS	Median	IV	0.195	0.430	.015	24	view →
DLBC	DFS	Tertile	All	1.000	0.520	.005	20	view →
CHOL	OS	Tertile	All	0.806	0.283	.006	17	view →
UCEC	DFS	Quartile	All	0.595	0.692	.017	14	view →
THCA	DFS	Median	III,IV	0.563	0.853	.016	14	view →
STAD	OS	Median	IV	0.550	0.237	.028	13	view →
COAD	OS	Median	III,IV	0.344	0.686	.015	11	view →
READ	OS	Quartile	IV	1.000	0.601	.029	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

MEGF11–UVM (DFS)

Open the UVM breakdown →