MEGF11

Across TCGA patient cohorts, MEGF11 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MEGF11-associated genes across cancer lineages are GSK-3_pS9, Src_pY416, and Src_pY527. Each is linked with MEGF11 in more than 1 cancer types. Because this analysis shows association rather than direction, both MEGF11-to-partner and partner-to-MEGF11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSK-3_pS9 grouped by MEGF11-low versus MEGF11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MEGF11→partner) and Y-score (partner→MEGF11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GSK-3_pS9 →	-0.288	-1.700	.026	.040	3	2
UCEC	Src_pY416 →	-0.188	-1.276	.014	.023	3	2
UCEC	Src_pY527 →	-0.424	-2.990	.002	<.001	3	2
UCEC	c-Met_pY1235 →	+0.065	+1.512	.005	.017	3	2
UCEC	4E-BP1 →	+0.337	+2.614	<.001	<.001	3	2
UCEC	eEF2 →	+0.318	+1.523	.005	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

GSK-3_pS9 by MEGF11 expression — UCEC

Explore this box plot interactively →