MEGF11

Across TCGA cell cohorts, MEGF11 mutation is significantly associated with the RNA expression of many other genes, with 46 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MEGF11-associated genes across cancer lineages are MDFIC2, SRY, and C6orf136. Each is linked with MEGF11 in more than 1 cancer types. Because this analysis shows association rather than direction, both MEGF11-to-partner and partner-to-MEGF11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MDFIC2 grouped by MEGF11-low versus MEGF11-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MEGF11→partner) and Y-score (partner→MEGF11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	MDFIC2 →	+0.055	+2.977	.002	.006	3	2
URINARY_TRACT	SRY →	+0.341	+4.584	<.001	.002	3	1
LARGE_INTESTINE	C6orf136 →	+0.533	+3.067	.002	.009	3	1
LARGE_INTESTINE	SMIM33 →	+0.500	+3.355	.001	.007	3	1
BLOOD_Leukemia	C6orf118 →	+0.045	+3.450	<.001	.004	3	1
BLOOD_Leukemia	TTLL2 →	+0.331	+3.736	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

MDFIC2 by MEGF11 expression — SKIN

Explore this box plot interactively →