MEGF11

Across TCGA cell cohorts, MEGF11 mutation is significantly associated with the mutation status of many other genes, with 3,676 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MEGF11-associated genes across cancer lineages are ARHGAP21, SUPT6H, and MYH10. Each is linked with MEGF11 in more than 4 cancer types. Because this analysis shows association rather than direction, both MEGF11-to-partner and partner-to-MEGF11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ARHGAP21 grouped by MEGF11-low versus MEGF11-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MEGF11→partner) and Y-score (partner→MEGF11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ARHGAP21 →	+2.146	+2.321	.008	.008	1	5
BLOOD_Leukemia	SUPT6H →	+2.825	+3.847	.001	.001	1	5
BLOOD_Lymphoma	MYH10 →	+4.014	+4.969	.008	.008	1	5
CNS	HK2 →	+5.862	+5.199	<.001	<.001	1	4
CNS	LMTK2 →	+3.541	+4.139	.003	.003	1	4
BLOOD_Lymphoma	CDK12 →	+5.014	+5.584	.003	.003	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,676 associations by consensus.

ARHGAP21 by MEGF11 expression — LARGE_INTESTINE

Explore this box plot interactively →