MEF2D

Across TCGA cell cohorts, MEF2D mutation is significantly associated with the RNA expression of many other genes, with 28 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MEF2D-associated genes across cancer lineages are CELA2A, H3-4, and DUSP21. Each is linked with MEF2D in more than 1 cancer types. Because this analysis shows association rather than direction, both MEF2D-to-partner and partner-to-MEF2D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CELA2A grouped by MEF2D-low versus MEF2D-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MEF2D→partner) and Y-score (partner→MEF2D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CELA2A →	+0.041	+4.099	<.001	<.001	3	1
SKIN	H3-4 →	+0.171	+3.459	.003	.009	3	1
LUNG_NSCLC_LUAD	DUSP21 →	+0.021	+4.813	<.001	<.001	3	1
LUNG_NSCLC_LUAD	HNRNPCL3 →	+0.020	+4.093	.004	.004	3	1
LARGE_INTESTINE	LGI1 →	+0.306	+3.029	.002	.006	3	1
LARGE_INTESTINE	OR12D3 →	+0.002	+3.700	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

CELA2A by MEF2D expression — SKIN

Explore this box plot interactively →