MEF2D

Across TCGA pan-cancer cohorts, MEF2D RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated MEF2D data layer compared with 9 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher MEF2D RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MEF2D expression acts as an unfavorable survival marker, although some lineages such as KIRC and UCS show a favorable association.

UVM, KIRC, and ACC are the cancer types where MEF2D RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	II,III,IV	0.377	0.746	<.001	76	view →
KIRC	OS	Tertile	All	0.769	0.576	<.001	75	view →
ACC	DFS	Median	All	0.275	0.622	<.001	64	view →
LUSC	OS	Tertile	II,III,IV	0.286	0.682	.002	33	view →
UCS	DFS	Median	II,III,IV	0.614	0.284	.008	30	view →
HNSC	DFS	Median	IV	0.751	0.577	.001	18	view →
KIRP	DFS	Median	All	0.806	0.896	.023	17	view →
THCA	OS	Median	All	0.964	1.000	.017	13	view →
BLCA	DFS	Median	All	0.226	0.475	.019	13	view →
PAAD	OS	Median	All	0.281	0.665	<.001	12	view →
READ	OS	Quartile	All	0.598	0.866	.012	12	view →
SKCM	OS	Quartile	III,IV	0.228	0.624	.002	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

MEF2D–UVM (DFS)

Open the UVM breakdown →