MEF2C

Across TCGA cell cohorts, MEF2C mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MEF2C-associated genes across cancer lineages are MMP26, OR2T6, and OR14A2. Each is linked with MEF2C in more than 1 cancer types. Because this analysis shows association rather than direction, both MEF2C-to-partner and partner-to-MEF2C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MMP26 grouped by MEF2C-low versus MEF2C-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MEF2C→partner) and Y-score (partner→MEF2C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MMP26 →	+0.027	+3.217	.002	.006	3	2
SOFT_TISSUE	OR2T6 →	+0.012	+4.930	<.001	.008	3	1
BREAST	OR14A2 →	+0.032	+5.169	<.001	.005	3	1
LARGE_INTESTINE	LY86 →	+0.063	+3.550	<.001	.004	3	1
LARGE_INTESTINE	OR2C1 →	+0.130	+3.426	<.001	.007	3	1
LARGE_INTESTINE	HMX3 →	+0.791	+3.531	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

MMP26 by MEF2C expression — LARGE_INTESTINE

Explore this box plot interactively →