MED9

Across TCGA patient cohorts, MED9 mutation is significantly associated with the RNA expression of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MED9-associated genes across cancer lineages are TNP1, RNU1-62P, and RN7SKP115. Each is linked with MED9 in more than 1 cancer types. Because this analysis shows association rather than direction, both MED9-to-partner and partner-to-MED9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TNP1 grouped by MED9-low versus MED9-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MED9→partner) and Y-score (partner→MED9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	TNP1 →	+0.141	+5.507	.001	<.001	3	1
CESC	RNU1-62P →	+0.192	+4.539	<.001	.008	3	1
CESC	RN7SKP115 →	+0.084	+5.144	<.001	.003	3	1
CESC	RNU6-12P →	+0.342	+4.705	<.001	.003	3	1
CESC	MIR920 →	+0.320	+4.539	<.001	.008	3	1
CESC	RPL12P23 →	+0.155	+4.816	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

TNP1 by MED9 expression — CESC

Explore this box plot interactively →