MED9

Across TCGA pan-cancer cohorts, MED9 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of MED9’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where MED9 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MED9 is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

HNSC, THCA, and KIRC are the cancer types where MED9 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MED9 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.482	<.001	10	view →
THCA	Male	III,IV	−0.642	.003	8	view →
KIRC	Male	II,III,IV	−0.606	<.001	8	view →
COAD	Female	All	−0.412	<.001	8	view →
LIHC	All	II,III,IV	+0.625	<.001	7	view →
KICH	All	All	−0.498	<.001	6	view →
CHOL	All	All	+1.305	<.001	5	view →
BRCA	All	All	−0.207	<.001	4	view →
READ	All	All	−0.563	.001	3	view →
STAD	All	II,III,IV	+0.397	.003	3	view →
ESCA	Male	All	+0.278	.047	2	view →
LUSC	All	All	+0.161	.045	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

MED9–HNSC

Open the HNSC breakdown →