MED28P8

Across TCGA pan-cancer cohorts, MED28P8 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of MED28P8’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where MED28P8 RNA is repressed in tumor relative to normal tissue. In most cancer types MED28P8 is over-expressed in tumor, although a few such as LUAD and LUSC show the opposite, repressed pattern.

LUAD, LUSC, and UCEC are the cancer types where MED28P8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MED28P8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	II,III,IV	−0.777	<.001	6	view →
LUSC	Female	All	−0.400	<.001	6	view →
UCEC	All	II,III,IV	−0.334	.024	4	view →
BRCA	All	II,III,IV	−0.012	.017	4	view →
LIHC	Male	All	−0.309	<.001	2	view →
THCA	All	III,IV	−0.300	.026	2	view →
KIRP	All	All	−0.031	.006	2	view →
HNSC	All	III,IV	+0.029	.049	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

MED28P8–LUAD

Open the LUAD breakdown →