Q-omics provides the consensus-scored MED28P8 profile across patient tissues and cancer cell-line models. MED28P8 expression is associated with patient survival in 17 of 34 cancer types, with the highest sampling consensus in READ. Among the 18 cancer types available for tumor–normal comparison, MED28P8 is differentially expressed in 8, with the highest sampling consensus in LUAD. Additionally, MED28P8 RNA expression shows 6,999 significant protein co-abundance associations, with the highest sampling consensus in GBM. Together, these results highlight READ, LUAD, and GBM as cancer lineages where MED28P8 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for MED28P8 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes MED28P8 survival associations across molecular data types. MED28P8 RNA expression shows survival associations in the most cancer types (17). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible MED28P8 RNA expression–survival associations across cancer types. High MED28P8 expression shows unfavorable associations in READ, HNSC, COAD, KIRC and UCEC, but favorable associations in OV. The READ Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify READ as the clearest survival context for MED28P8 RNA expression.
This table summarizes MED28P8 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 8. The strongest signals are observed in LUSC for RNA.
This table ranks reproducible tumor–normal expression differences for MED28P8. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. MED28P8 shows lower tumor expression in LUAD, LUSC, UCEC, BRCA, LIHC and THCA. The LUAD box plot shows higher MED28P8 RNA expression in normal versus tumor tissue (log2 FC = −0.777, t-test p < 0.001).
This table shows molecular features associated with MED28P8 in patient tissues and cancer cell lines. In patient samples, MED28P8 shows the broadest associations at the RNA and protein expression levels, with GBM recurring as the lineage with the largest associated feature set.
