MED18

Across TCGA patient cohorts, MED18 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MED18-associated genes across cancer lineages are S6_pS235_S236, YB-1, and eEF2. Each is linked with MED18 in more than 1 cancer types. Because this analysis shows association rather than direction, both MED18-to-partner and partner-to-MED18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, S6_pS235_S236 grouped by MED18-low versus MED18-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MED18→partner) and Y-score (partner→MED18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	S6_pS235_S236 →	+0.515	+3.000	.040	.037	3	1
UCEC	YB-1 →	+0.199	+3.026	.029	.019	2	1
UCEC	eEF2 →	+0.549	+3.000	.007	.037	1	1
UCEC	eIF4G →	+0.373	+3.000	.037	.037	1	1
UCEC	ACC_pS79 →	+0.506	+3.000	.011	.037	1	1
UCEC	GATA6 →	-0.219	-2.992	.014	.036	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

S6_pS235_S236 by MED18 expression — UCEC

Explore this box plot interactively →