MEAK7

Across TCGA patient cohorts, MEAK7 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MEAK7-associated genes across cancer lineages are Notch1, p21, and VEGFR2. Each is linked with MEAK7 in more than 1 cancer types. Because this analysis shows association rather than direction, both MEAK7-to-partner and partner-to-MEAK7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by MEAK7-low versus MEAK7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MEAK7→partner) and Y-score (partner→MEAK7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.191	+3.009	.007	.019	3	1
UCEC	p21 →	+0.214	+2.321	.026	.035	3	1
UCEC	VEGFR2 →	+0.386	+3.009	.009	.019	3	1
UCEC	Cyclin-B1 →	+0.831	+3.169	.003	.019	3	1
UCEC	eIF4G →	+0.439	+3.169	.004	.019	2	1
UCEC	4E-BP1 →	+0.385	+2.321	.004	.035	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Notch1 by MEAK7 expression — UCEC

Explore this box plot interactively →