MEAK7

Across TCGA pan-cancer cohorts, MEAK7 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated MEAK7 data layer compared with 2 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher MEAK7 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MEAK7 expression acts as an unfavorable survival marker, although some lineages such as UCS and BLCA show a favorable association.

ACC, LUAD, and HNSC are the cancer types where MEAK7 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.395	0.758	<.001	105	view →
LUAD	DFS	Median	All	0.600	0.728	<.001	105	view →
HNSC	OS	Tertile	III,IV	0.516	0.691	.002	88	view →
PAAD	DFS	Tertile	All	0.402	0.625	<.001	60	view →
BRCA	OS	Quartile	II,III,IV	0.880	0.954	.002	54	view →
LIHC	OS	Median	All	0.609	0.761	<.001	50	view →
LUSC	DFS	Median	All	0.300	0.462	.002	34	view →
LGG	OS	Median	All	0.854	0.936	<.001	32	view →
SKCM	OS	Quartile	All	0.848	0.935	.002	26	view →
UCS	DFS	Quartile	II,III,IV	0.533	0.154	.002	20	view →
MESO	DFS	Tertile	All	0.318	0.669	.012	17	view →
DLBC	DFS	Median	All	0.322	0.858	.003	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

MEAK7–ACC (DFS)

Open the ACC breakdown →