MEAK7

Across TCGA pan-cancer cohorts, MEAK7 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of MEAK7’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where MEAK7 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MEAK7 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, KIRP, and THCA are the cancer types where MEAK7 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MEAK7 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	IV	+1.815	<.001	11	view →
KIRP	All	IV	+1.750	<.001	11	view →
THCA	Male	III,IV	−0.574	<.001	11	view →
LUAD	Male	II,III,IV	+1.217	<.001	8	view →
LIHC	All	II,III,IV	+0.485	<.001	8	view →
LUSC	Male	All	+0.909	<.001	6	view →
BLCA	All	III,IV	+0.726	.008	6	view →
CHOL	Male	All	+2.250	<.001	5	view →
KICH	All	All	−0.795	<.001	5	view →
KIRC	Male	All	+0.383	<.001	4	view →
COAD	Male	II,III,IV	+0.338	.002	3	view →
PAAD	All	All	+0.844	.045	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

MEAK7–HNSC

Open the HNSC breakdown →